American actress Mikey Madison, born on March 25, 1999, in Los Angeles, California, is recognized for her portrayal of Susan "Sadie" Atkins, a member of the Manson Family, in Quentin Tarantino's film Once Upon a Time in Hollywood (2019). She further solidified her acting reputation with roles in the series Better Things (2016–2022) and the horror movie Scream (2022).

In 2025, Madison marked a significant achievement by winning the Academy Award for Best Actress for her performance as Ani in Sean Baker's Anora. The narrative follows a lap dancer from Brooklyn who becomes entangled with a young Russian oligarch while navigating their complex relationship. Madison's portrayal received acclaim for its authenticity and depth, which played a role in the film’s success among critics. Anora was nominated for five Oscars including Best Picture, Best Director, Best Original Screenplay, and Best Editing.

The Oscar win was viewed as unexpected since many anticipated Demi Moore would take home the award for her work in The Substance. Nonetheless, Madison gained momentum following her BAFTA victory that ultimately led to recognition at the Academy Awards. During her acceptance speech, she thanked the sex worker community for their influence on her character.